The AWSEM-MD Frustratometer is an Energy Landscape Theory inspired algorithm that aims at quantifying the degree of local frustration manifested in protein molecules. Frustration is a useful concept for gaining insights about the biological behavior of proteins by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift the energy distributions. Sites of high local frustration often indicate biologically important regions such as binding or allosteric sites. Minimally frustrated linkages constitute a stable folding core of the molecule. Thanks to its improved architecture and speed, this new version allows to calculate frustration on much larger protein structures and multimers. Additionally the effect of electrostatics on the local frustration values can be modelled.

Check out this paper for a recent review of the biological effects of local frustration analysis. For a deeper discussion of the basics of frustration biophysics please refer to this other one

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